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ALK (Anaplastic Lymphoma Kinase) [SP8]

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Ref: AP10016C - Clone: SP8 - Host: Rabbit - Method: P - Format: Concentrated
DS  Imagen 1   MSDS  Imagen 2
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Manufacturer: Gennova
Description

SUMMARY, EXPLANATION AND LIMITATIONS:
This antibody recognizes human p80 protein of 80 kDa, identified as a hybrid gene Anaplastic lymphoma kinase (ALK) and nucleophosmin gene (NPM), as a result of translocation t (2;5)(p23;q35) detected in one third of large cell lymphomas.
 
Clone: SP8
Isotype: IgG
Immunogen: Recombinant protein corresponding to a region covering the catalytic domain of tyrosine kinase and a part of the C-terminal NPM-ALK transcript.
Staining pattern: Cytoplasmic and nuclear.
Positive control: Tissue sample from anaplastic lymphoma.

APPLICATIONS:
This antibody is designed for the specific localization of human ALK using IHC techniques in formalin-fixed, paraffin-embedded tissue sections.
This monoclonal antibody obtained in rabbit can be used to detect p80 in large cell lymphomas and it can in turn be used to detect a subtype of large B-cell lymphoma recently described for its expression of complete protein ALK.

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