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b-Catenin [Polyclonal]

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Ref: AP10044 - Clone: Polyclonal - Host: Rabbit - Method: P - Format: Ready to use
DS  Imagen 1   MSDS  Imagen 2
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Manufacturer: Gennova
Description

SUMMARY, EXPLANATION AND LIMITATIONS:
The catenins (alpha, Beta and gamma) are ubiquitously expressed, cytoplasmic proteins associated with E-cadherin at cellular junctions. b-catenin also binds to N-cadherin and co-immunoprecipitates with APC. Cadherin/catenin complexes are linked to the cytoskeleton via a direct association between alpha-actinin and alpha-catenin. Increases tyrosine phosphorylation can disrupt catenin-cadherin complexes, influencing cellular adhesion.

Polyclonal
Isotype: IgG
Immunogen: A 92kDa synthetic peptide from the C-terminus of the b-catenin protein.
Staining pattern: Cytoplasmic and cell membrane.
Positive control: Tissue sample from breast or skin.

APPLICATIONS:
This antibody is designed for the specific localization of human b-Catenin using IHC techniques in formalin-fixed, paraffin-embedded tissue sections.

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