RT Spectral - шаблон joomla Новости

CD23 [1B12]

Ref: AP10092 - Clone: 1B12 - Host: Mouse - Method: P - Format: Ready to use
DS  Imagen 1   MSDS  Imagen 2
Rating: Not Rated Yet
Manufacturer: Gennova

CD23 is a 45kDa glycoprotein that acts as a receptor for IgE. It is expressed by interleukin-4 activated B-lymphocytes, by activated macrophages, and by a proportion of follicular dentritic cells. CD23 has been shown to be useful for the differentiation of small lymphocytic lymphomas and mantle cell lymphoma.

Clone: 1B12
Isotype: IgG1
Immunogen: Recombinant external domain of CD23 protein.
Staining pattern: Cell membrane.
Positive control: Tissue sample from tonsil.

This antibody is designed for the specific localization of human CD23 using IHC techniques in formalin-fixed, paraffin-embedded tissue sections.
CD23 expression was detected in neoplastic lymphoid cells of chronic lymphocytic leukemia B (73-90% of cases), a variable percentage of follicular lymphomas and in a small proportion of large cell lymphomas, in this case and coinciding with the coexpression of CD40 as a way indicative of better prognosis.
Furthermore and although the CD23 molecule is produced by B cells is adsorbed in large quantity on follicular dendritic reticulum cells thus is also used for the identification of their tumors (dendritic reticulum cell sarcoma).


There are yet no reviews for this product.