SUMMARY, EXPLANATION AND LIMITATIONS:
CD31 is also called PECAM-1 for platelet endothelial cell-adhesion molecule. It plays a key role in removing aged neutrophils from the body. CD-31 is normally found on stem cells, endothelial cells, platelets, macrophages and Kupffer cells, granulocytes, T/NK cells, lymphocytes, megakaryocytes, fibroblasts, osteoclasts and neutrophils. CD-31 is also expressed in certain tumors, including Epithelioid Hemangioendothelioma, Epithelioid Sarcomalike Hemangioendothelioma, other vascular tumors, Histiocytic malignancies, and Plasmacytomas. It is rarely found in some sarcomas and carcinomas. CD-31 and macrophages play a key role in tissue regeneration.
Immunogen: Recombinant protein corresponding to the extracellular domain of human CD31.
Staining pattern: Cell membrane.
Positive control: Tissue sample from tonsil, placenta or appendix.
This antibody is designed for the specific localization of human CD31 using IHC techniques in formalin-fixed, paraffin-embedded tissue sections.