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CD44 [156-3C11]

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Ref: AP10110 - Clone: 156-3C11 - Host: Mouse - Method: P - Format: Ready to use
DS  Imagen 1   MSDS  Imagen 2
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Manufacturer: Gennova
Description

SUMMARY, EXPLANATION AND LIMITATIONS:
CD44 antigen is a transmembranous glycoprotein (80 kDa) antibody that is specific forepitope 3 of the CD44 H molecule. CD44 (HCAM) is a cell adhesion molecule that plays an important role in the cascade of metastasis and progression of human malignant tumours. CD44 antigen is present on T lymphocytes, granulocytes, red blood cells, brain and epithelial cells. The standard isoform, CD44s, are also expressed in a wide range of normal tissues such as tonsil, skin, bladder and cervical squamous epithelium. In breast cancer studies, CD44 expression, as assessed by immunohistochemical staining demonstrated a favorable prognostic factor in patients with node-negative invasive breast carcinoma. Further studies have shown a subpopulation of CD44+/CD24- in breast cancer cells have stem/progenitor cell properties.

Clone: 156-3C11
Isotype: IgG2a
Immunogen: Stimulated human leukocyte
Staining pattern: Cell membrane/cytoplasmic.
Positive control: Tissue sample from breast cancer or tonsil.

APPLICATIONS:
This antibody is designed for the specific localization of human CD44 using IHC techniques in formalin-fixed, paraffin-embedded tissue sections.

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