SUMMARY, EXPLANATION AND LIMITATIONS:
CDX2 is a gene that encodes an intestine-specific transcription factor that is expressed early in intestinal development and may be involved in the regulation of proliferation and differentiation of intestinal epithelial cells. It is expressed in the nuclei of epithelial cells throughout the intestine, from duodenum to rectum. The CDX2 protein is expressed in primary and metastatic colorectal carcinomas and has also been demonstrated in the intestinal metaplasia of the stomach and intestinal-type gastric cancer, while it is not expressed in the normal gastric mucosa. Studies have shown that CDX2 is superior marker compared to CK20.
Immunogen: Prokaryotic recombinant protein corresponding to the 180 amino acid N-terminal region of the human CDX2 molecule.
Staining pattern: Nucleus.
Positive control: Tissue sample from colon.
This antibody is designed for the specific localization of human CDX2 using IHC techniques in formalin-fixed, paraffin-embedded tissue sections.