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HHV8 [LN35]

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Ref: AP10382C - Clone: LN35 - Host: Rat - Method: P - Format: Concentrated
DS  Imagen 1   MSDS  Imagen 2
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Manufacturer: Gennova
Description

SUMMARY, EXPLANATION AND LIMITATIONS:
HHV-8, also designated Kaposi’s sarcoma-associated herpesvirus is associated with multicentric Castleman’s disease and primary effusion lymphoma, a rare type of non-Hodgkin lymphoma affecting the body cavities. HHV-8 K14 is expressed at the surfaces of infected cells solely during the lytic cycle. It interacts with human CD200R, a receptor expressed on myeloid cells that is involved in locally restricting macrophage activation. The interaction of HHV-8 K14 with CD200R allows the protein to locally restrain macrophage activation by inhibiting TNFα production. HHV-8 encodes a viral-cyclin that is homologous to cellular D-type cyclins, a class of positive cell cycle mediators that are physiologically regulated by the p27 cell cycle inhibitor. HHV-8 cyclin is not sensitive to p27, however, which may explain the coexistence of p27 and high proliferative index of HHV-8 observed in individuals with primary effusion lymphoma (PEL).

Clone: LN35
Isotype: IgG2c
Immunogen: Recombinant protein corresponding to the latent nuclear antigen 1 molecule of HHV8.
Staining pattern: Nuclear.
Positive control: Tissue sample from Kaposi´s sarcoma.

APPLICATIONS:
This antibody is designed for the specific localization of human HHV8 using IHC techniques in formalin-fixed, paraffin-embedded tissue sections.

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