SUMMARY, EXPLANATION AND LIMITATIONS:
Papillomaviruses are a diverse group of DNA-based viruses that infect the skin and mucous membranes of humans and a variety of animals. More than 100 different human papillomavirus (HPV) types have been characterized. Some HPV types cause benign skin warts, or papillomas, for which the virus family is named. HPVs associated with the development of such “common warts” are transmitted environmentally or by casual skin-to-skin contact. A separate group of about 30 HPVs are typically transmitted through sexual contact. Some sexually transmitted HPVs, such as types 6 and 11, can cause genital warts. However, most HPV types that infect the genitals tend not to cause noticeable symptoms. Persistent infection with a subset of about a dozen so-called “high-risk” sexually transmitted HPVs, including types 16, 18, 31, 33, 35, 39, 45 and 51, can lead to the development of Cervical Dyskaryosis, which may in turn lead to cancer of the cervix. HPV infection is a factor in the development of nearly all cases of Cervical Cancer. Anti-human papillomavirus, clone SB24 reacts with an epitope of a major capsid protein of HPV, which is broadly expressed among the different HPV subtypes.
Staining pattern: Nuclear.
Positive control: Tissue sample infected with HPV.
This antibody is designed for the specific localization of human HPV using IHC techniques in formalin-fixed, paraffin-embedded tissue sections.