SUMMARY, EXPLANATION AND LIMITATIONS:
The inhibin alpha subunit joins either the beta A or beta B subunit to form a pituitary FSH secretion inhibitor. Inhibin has been shown to regulate gonadal stromal cell proliferation negatively and to have tumour-suppressor activity. In addition, serum levels of inhibin have been shown to reflect the size of granulosa-cell tumors and can therefore be used as a marker for primary as well as recurrent disease. However, in prostate cancer, expression of the inhibin alpha-subunit gene was suppressed and was not detectable in poorly differentiated tumor cells. Furthermore, because expression in gonadal and various extragonadal tissues may vary severalfold in a tissue-specific fashion, it is proposed that inhibin may be both a growth/differentiation factor and a hormone.
Immunogen: Syntetic peptide according to human inhibin a.
Staining pattern: Cytoplasmic.
Positive control: Tissue sample from testis, ovary.
This antibody is designed for the specific localization of human Inhibin a using IHC techniques in formalin-fixed, paraffin-embedded tissue sections.