SUMMARY, EXPLANATION AND LIMITATIONS:
MSH6 (mutS homologue 6) belongs to the so-called mismatch repair proteins (MMR proteins) like MLH1, MLH3, MSH2, MSH3, MSH4, MSH5, PMS1, and PMS2. Defects in the genes coding for these proteins lead to microsatellite instability (MSI) and considerable higher mutation rates. Hereditary nonpolyposis colorectal cancers (HNPCC) often show germline mutations in the mmr protein associated genes. These mutations result in decreased or abnormal protein production. The majority of HNPCC is characterised by damages in the MLH1 and MSH2 encoding genes, sometimes also in damages in MSH6 and PMS2 encoding genes.
Immunogen: Synthetic human MSH6 peptide.
Staining pattern: Nuclear.
Positive control: Tissue sample from tonsil or colon.
This antibody is designed for the specific localization of human MSH-6 using IHC techniques in formalin-fixed, paraffin-embedded tissue sections.
Defects in this protein are a cause of hereditary nonpolyposis colorectal cancer (HNPCC) or Lynch syndrome in attributing sporadic neoplastic colorectal, gastric and endometrial prognostic value.