SUMMARY, EXPLANATION AND LIMITATIONS:
NFkB (nuclear factor kB) regulates the expression of a large number of genes that play critical roles in apoptosis, viral replication, tumorigenesis, various autoimmune diseases and inflammation. The active nuclear form of the NFkB transcription factor complex is composed of two DNA binding subunits, NFkB/p65 and p50, both of which share extensive N terminal sequence homology with the v-rel oncogene product. N terminal regions of p50 and p65 are critical for DNA binding and help determine the DNA binding specificities of p50 and p65.
Immunogen: A synthetic peptide corresponding to internal domain of human NFkB/p65.
Staining pattern: Nuclear.
Positive control: Tissue sample from tonsil or placenta.
This antibody is designed for the specific localization of human NFkB/p65 using IHC techniques in formalin-fixed, paraffin-embedded tissue sections.