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p57Kip2 [Polyclonal]

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Ref: AP10480 - Clone: Polyclonal - Host: Rabbit - Method: P - Format: Ready to use
DS  Imagen 1   MSDS  Imagen 2
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Manufacturer: Gennova
Description

SUMMARY, EXPLANATION AND LIMITATIONS:
p57Kip2 (or CDKN1C) is a potent tight-binding inhibitor of several G1 cyclin complexes, and is a negative regulator of cell proliferation. The gene encoding human p57Kip2 is located on chromosome 11p15.5, a region implicated in both sporadic cancers, Wilm's tumor, and Beckwith-Wiedemann syndrome (BWS), a cancer syndrome, making it a tumor suppressor candidate. BWS is characterized by numerous growth abnormalities and an increased risk of childhood tumors. Several types of childhood tumors including Wilms' tumor, adrenocortical carcinoma and rhabdomyosarcoma display a specific loss of maternal 11p15 alleles, suggesting that genomic imprinting plays an important part. This region also contains two other imprinted genes, insulin-like growth factor II (IGF-II) and H19, both of which seem to be implicated in adrenal neoplasms.

Polyclonal
Isotype: IgG
Immunogen: A synthetic peptide from human p57Kip2 protein.
Staining pattern: Nuclear.
Positive control: Tissue sample from colon carcinoma or placenta.

APPLICATIONS:
This antibody is designed for the specific localization of human p57kip2 using IHC techniques in formalin-fixed, paraffin-embedded tissue sections.

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