SUMMARY, EXPLANATION AND LIMITATIONS:
Substance P, an 11-amino acid peptide, is part of the tachykinin peptide hormone family that includes neurokinin A, as well as the related peptides, neuropeptide K and neuropeptide gamma. These hormones are thought to function as neurotransmitters which interact with nerve receptors and smooth muscle cells. Substance P is normally present at relatively high concentrations in nerve endings in selected regions of the mammalian brain. It is present in dorsal root ganglion (primary sensory) neurons and has been functionally linked to pain. The specific receptor subtype that corresponds to substance P is neurokinin 1 receptors, and this neurotransmitter appears to play a key role in the regulation of emotions.
Immunogen: Synthetic substance P conjugated to KLH.
Staining pattern: Cytoplasmatic.
Positive control: Tissue sample from appendix or cerebellum.
This antibody is designed for the specific localization of human substance P using IHC techniques in formalin-fixed, paraffin-embedded tissue sections.